Alanna F. Bree, MD

Alanna F. Bree, M.D. is a double board-certified Pediatric Dermatologist, as well as the Founder and President of the Board for Made A Masterpiece™.  She is passionate about making the world a better place for children impacted by skin conditions and birthmarks by supporting their social and emotional needs so they can truly love the skin they are in and face the world with confidence. She also loves building relationships and collaborating with others since she wholeheartedly believes we are better when we work together and lift one another to be the best version of ourselves.

In addition, she enjoys teaching about pediatric dermatology and raising awareness about the impact of living with a skin condition so the world can be a more understanding, accepting, and loving place for those with visible skin differences. She is excited to join the Sagis team as the Director of Pediatric Dermatology Collaboration and use her previous experiences and skills to grow this new area of focus for this amazing patient-focused and philanthropic organization. Dr. Bree is now a featured guest on our Dermpath Happy Hour Sessions.

Professionally, Dr. Bree has worked in both academic and private practice settings. She retired from the clinical practice of Pediatric Dermatology in 2022. She has been actively involved in the American Academy of Dermatology and Society for Pediatric Dermatology, where she has participated in several leadership roles & given many nationally invited lectures. She has been involved in national and international pediatric dermatology research with NIH grant funding for her work on AEC Syndrome, has several scientific publications, and is co-author of The Illustrated Manual of Pediatric Dermatology. She has been a long-time volunteer at the American Academy of Dermatology’s Camp Discovery. She is also a previous member of the Scientific Advisory Council for the National Foundation for Ectodermal Dysplasias, and was co-chair of the Dermatology Advisory Group for the World Health Organization to update the International Classification of Diseases.

Dr. Bree has additionally authored her own book, A Children’s House: A Little Story About A God-sized Dream, which is a personal testimony of all God has done in and through her life. She desires that her work brings glory to God and spreads the love and light of Jesus to a hurting world that needs His mercy and grace for complete healing. In truth, she considers that to be the best medicine of all for every heart and soul!

Sagis is grateful to partner with Dr. Alanna Bree and officially sponsor Made A Masterpiece.

Research

• Co-Investigator, International Research Symposium on Goltz Syndrome, 7/22-23/2013 (completed).

• Co-Investigator, Determining the Feasibility of Using iPS Cells for the Treatment of Skin Erosions in AEC Patients, 7/2011 (completed).

• Co-Investigator, Evaluation of Phenotypic Properties in Male Subjects Affected by Hypohidrotic Ectodermal Dysplasia: Intrafamilial Variation, 7/2011 (completed).

• Co-Investigator, Evaluation of Phenotypic and Genetic Properties in Male Subjects Affected by Hypohidrotic Ectodermal Dysplasia, 6/2010, (completed).

• Principal Investigator, A 2-3 year open-label phase to evaluate the effect of early intervention versus delayed intervention with Elidel on the incidence of asthma in children. 2/2008, (completed).

• Principal Investigator, The Use of a Survey in Evaluation the Impact of Camp for Children with Skin Disease. 8/2007 (completed).

• Principal Investigator, International Research Symposium on Ankyloblepharon-Ectodermal Defects-and Cleft Lip and/or Palate (AEC) Syndrome, 11/2006, (completed).

• Co-Investigator, Prevalence of Atopic Disorders and Immune Deficiency in Individuals Affected by Ectodermal Dysplasia Syndromes survey, 9/2005, (completed)

• Sub-Investigator, A multicenter open-label study of the safety and efficacy of repeated treatments with BOTOX (botulinum toxin type A) purified neurotoxin complex for primary axillary hyperhidrosis in adolescents, 8/2005 (completed)

• Principal Investigator, Screening for insulin resistance-related syndromes in children with acanthosis nigricans, 8/2004 (completed)

• Participant, National Science Foundation Regional Grants Conference, Washington University School of Medicine, 10/2004 (completed)

• Principal Investigator, A randomized, investigator blinded, active controlled, parallel-group study to compare the efficacy and safety 6-week treatment with terbinafine new pediatric formulation versus 6-week treatment with griseofulvin pediatric suspension in children with tine capitals, 8/2004 (completed)

• Sub-Investigator, A multi-center retrospective study to evaluate the safety of BOTOX (botulinum toxin type A) purified neurotoxin complex for the treatment of primary hyperhidrosis based on review of patient charts, 11/2003-1/2004 (completed)

• Sub-Investigator, A multicenter, randomized, double-blind, double-dummy, parallel group study to assess the efficacy, safety and tolerability of new oral formulation terbinafine in patients with onychomycosis of the toenails, Saint Louis University Department of Dermatology, 5/2001-10/2003 (completed)

• Clinical Research Assistant and Project Coordinator, Department of Pathology, Washington University School of Medicine, 5/1994-7/1995

• Research Assistant, Department of Microbiology, Southwest Missouri State University, 1/1993-5/1994

Publications

1. Schachner LA, Andriessen A, Benjamin L, Bree AF, Lechman PA, Pinera-Llano AA, Kircik L, Hebert A. The Importance of Skincare for Neonates and Infants: An Algorithm. J Drug Dermatol 2021, 20(11): 1195-1205.

2. Schachner LA, Andriessen A, Benjamin L, Bree AF, Leachman PA, Pinera-Llano AA, Kircik LH. A Consensus About the Importance of Ceramide Containing Skincare for Normal and Sensitive Skin Conditions in Neonates and Infants. J Drug Dermatol 2020, 19(8): 769-776.

3. Dinella J, Chen J, Webb S, Siegfried E, Bree AF, Koster MI, Koch PJA Human Stem Cell-Based System to Study the Role of TP63 Mutations in Ectodermal Dysplasias. J Invest Dermatol 2018.

4. Bree AF, Grange DK, Hicks MJ, Goltz RW. Dermatologic Findings of Focal Dermal Hypoplasia (Goltz Syndrome). Am J Med Genet C Semin Med Genet 2016, 172(1):44-51.

5. Bree AF, Siegfried EC. Acne Vulgaris in Preadolescent Children: Recommendations for Evaluation. Pediatr Dermatol 2014, 31(1):27-32.

6. Bree AF, Cole P, Siegfried EC. A Love of Dermatology. JAMA Dermatol 2014 Feb 150(2):121-2.

7. Mark BJ, Becker BA, Halloran DR, Bree AR, Sindwani R, Fete MD, Motil KJ, Srun SW, Fete TJ. The Prevalence of Atopic Disorders and Immunodeficiency in Individuals Affected by Ectodermal Dysplasia Syndromes. Ann Allergy Asthma Immunolo 2012 Jun, 108(6): 435-8.

8. Bree AF, Shah MR. Consensus Statement from the First International Colloquium on Basal Cell Carcinoma Nevus Syndrome. Am J Med Genet A. 2011 Sep; 155(9):2091-7.

9. Tom WL, Hurley MY, Oliver D, Shah MR, Bree AF. Features of Basal Cell Carcinomas in Basal Cell Nevus Syndrome. Am J Med Genet A. 2011 Sep; 155(9):2098-104.

10. Shah M, Mavers M, Bree A, Fosko S, Lents NH. Quality of life and depression assessment in nevoid basal cell carcinoma syndrome. Int J Dermatol. 2011 Mar; 50(3):268-76.

11. Lifton R, Bree AF, Choate K, Choi M, Crumrine D, Elias P, Farhi A, Lu Y, Milstone L, Nelson-Williams C, Nopper A, Williams M, Zhou J. Mitotic recombination in patients with ichthyosis causes reversion of dominant mutations in KRT 10. Science. 2010 Oct 1; 330(6000):94-7.

12. Bree AF. Clinical lessons learned from the international research symposium on ankyloblepharon-ectodermal defects-cleft lip/palate (AEC) syndrome. Am J Med Genet A. 2009; 149A(9):1894-99.

13. Julapalli MR, Siegfried EC, Sybert VP, Scher RK, Bree AF. Dermatological findings of AEC syndrome. Am J Med Genet A. 2009; 149A(9):1900-06.

14. Dishop MK, Bree AF, Hicks MJ. Pathologic features of skin and hair in ankyloblepharon-ectodermal defects-cleft lip/palate (AEC) syndrome. Am J Med Genet A. 2009; 149A(9):1935-41.

15. Sutton VR, Plunkett K, Dang DZ, Lewis RA, Bree AF, Baino CA. Craniofacial and anthropometic phenotype in ankyloblepharon-ectodermal dysplasia-cleft lip/palate syndrome (Hay-Wells Syndrome) in a cohort of 17 patients. Am J Med Genet A. 2009; 149A(9):1916-21.

16. Cole P, Hatef DA, Kaufman Y, Magruder A, Bree A, Friedman E, Sindwani R, Hollier LH Jr. Facial clefting and oroauditory pathway manifestations in ankyloblepharon-ectodermal defects-cleft lip/palate (AEC) syndrome. Am J Med Genet A. 2009; 149A(9):1910-15.

17. Lane MM, Dalton WT, Sherman SA, Bree AF, Czyzewski DI. Psychosocial functioning and quality of life in children with AEC syndrome and their families. Am J Med Genet A. 2009; 149A(9):1926-34.

18. Fete M, vanBokhoven H, Clements S, McKeon F, Roop D, Koster M, Missero C, Attardi L, Lombillo VA, Ratovitski E, Fromenkov A, Julapilli M, Ruths D, Sybert VP, Siegfried EC, Bree AF. Conference Report: International Research Symposium on Ankyloblepharon-Ectodermal Defects-Cleft Lip and/or Palate (AEC) Syndrome. Am J Med Genet A. 2009; 149A(9):1885-93.

19. Browning JC, Eldin KW, Kozakewich HPW, Mulliken JB, Bree AF. Congenital disseminated pyogenic granulomas. Pediatr Dermatol 2009 May-Jun; 26(3):323-27.

20. Siegfried E, Glaser D, Bree A, Fete M, Sybert V. Skin erosions and wound healing in ankyloblepharonectoderal defect – cleft lip and/or palate. Arch Dermatol. 2005 Dec; 141(12): 1591-4.

21. Kilcline C, Shinkai K, Bree A, Modica R, Von Scheven E, Frieden IJ. Neonatal Onset Multisystem Inflammatory Disorder (NOMID): The emerging role of pyrin genes in autoinflammatory disease. Arch Dermatol 2005; 141(2):248-53.

22. Bree AF, Siegfried E, Sotelo C, Nahass G. Infantile Hemangiomas; Speculation on Placental Trophoblastic Origin. Arch Dermatol 2001; 137:573-7.

23. Liapis H, Flath A, Steinhardt G. Increased expression of platlet-derived growth factor A and collagenous matrix proteins in congenital mulicystic renal dysplasia. Nephron 1997; 76:161-70.

24. Liapis H, Flath A, Kitazawa MD. Integrin alphaV-beta3 expression by bond-residing breast cancer metastases. Diag Mol Path 1996:5(2): 127-35.

25. Liapis H, Flath A, Smith JW. Tubular epithelial integrins are downregulated in cystic renal dysplasia. Lab Invest 1995:72(1):160A(936).

26. Liapis H, Davila RM, Flath A, Smith JW. Developmental expression of alphaV-beta3, alphaV-beta5 and alphaV-beta1 integrin receptors in fetal and adult kidneys. Lab Invest 1995;72(1):160A(937).

Internet and Other Publications

• Bree AF. Orphanet: AEC Syndrome. July 2013.

• Sutton VR, Bree AF, van Bokhoven H: Ankyloblepharon-Ectodermal Defects-Cleft Lip/Palate Syndrome. In: Pagon RA, Bird TD, Dolan CR, Stephens K, editors. Gene Reviews [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2010 Jun 8.

• Bree AF. Ectodermal Dysplasias: Don’t Sweat It. Skin & Aging. June 2009 TD, Dolan CR, Stephens K, editors. GeneReviews [Internet]. Seattle (WA): University of Washington, Seattle, 1993- 2010 Jun 8.

• CINCA Syndrome. DermAtlas.org. March 2004.

Books

• Mallory S, Bree AF. Illustrated Manual of Pediatric Dermatology. Taylor and Francis, New York, NY, 2005.

• Bree AF. A Children’s House: A Little Story about a God-sized Dream. Stellar Communications, Houston, TX, 2018.

Book Chapters

• Nelson EE, Bree AF. Approach to Alopecia Areata. In: Toy EC, Toy AL, eds. Case Files Pediatrics Online. New York: McGraw Hill Publishers, In Press. 

• Bree AF. Pre-operative and post-operative care of children in Pediatric Dermatologic Surgery, 1st edition, Wiley, 2015. 

• Bree AF. Hypohidrotic Ectodermal Dysplasia in Clinical Decision Support: Dermatology. 2013. 

• Bree AF. Hidrotic Ectodermal Dysplasia in Clinical Decision Support: Dermatology. 2013. 

• Bree AF. AEC Syndrome in Clinical Decision Support: Dermatology. 2013. 

• Bree AF. Ectodermal dysplasias in Clinical Decision Support: Pediatrics. 2013. 

• Bree AF, Sybert V. Ectodermal Dysplasias in Fitzpatrick’s Dermatology in General Medicine, 7th edition, Wolff K, Goldsmith LA, Katz SI, editors. McGraw-Hill Companies, Columbus, OH. 2012. 

• Bree AF, Sybert V. Ectodermal Dysplasias in Dermatology, 3rd edition, Bolognia J, editor.Elsevier, London. 2012.

• Bree AF, Paller A. Genodermatoses; in Pediatric Dermatology; 4th edition, Schachner LA and Hansen RC, editors. Elsevier, London. 2011. 

• Maronn M, Siegfried E, Bree AF. Principles of Treatment; in Pediatric Dermatology; 4th edition, Schachner LA and Hansen RC, editors. Elsevier, London. 2011. 

• Browning J, Bree AF. Juvenile Plantar Dermatosis; in Harper’s Textbook of Pediatric Dermatology; 3rd edition, Irvine AD, Hoeger PH, Yan AC, editors. Wiley-Blackwell, Oxford, London, 2011.

• Headon DJ, Overbeek PA, Bree AF. Hypohidrotic Ectodermal Dysplasia; in Encyclopedia of Molecular Mechanisms of Disease, Springer, New York, NY, 2009. 

• Bree AF, Siegfried EC. Neonatal Skin Care and Toxicology; in Textbook of Neonatal Dermatology, 2nd edition, Eichenfield, LF, Frieden IJ, Esterly NB, editors. W.B. Sauders Company, Philadelphia, PA, pp. 59-72, 2008. 

• Levy M, Bree A, The genodermatoses. In: Up To Date. Rose BD (ed), UpToDate, Waltham, MA. 2007. 

• Bree AF, Nopper AJ, Siegfried EC. Principles of Treatment; in Pediatric Dermatology, Schachner LA, Hansen RC, editors. W.B. Sauders Company, Philadelphia, PA, pp. 87-114, 2003.